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A gene for the constitutive ribosephosphate isomerase ( rpiA ) is highly cotransducible with serA at 56.2 min on the genetic linkage map of Escherichia coli K-12. Suppression of ribosephosphate isomerase A-negative mutants can occur by a regulator gene mutation permitting constitutive synthesis of the normally inducible ribosephosphate isomerase B.
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SKINNER et al. (1974) studied this question.
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