September 22, 2014Clinical Chemistry and Laboratory Medicine (CCLM)
Recent guidelines and recommendations for laboratory assessment of the direct oral anticoagulants (DOACs): is there consensus?
Why the study?
What are the consensus guidelines and recommendations for laboratory assessment of direct oral anticoagulants?
Population
Patients taking direct oral anticoagulants (DOACs) including dabigatran, rivaroxaban, apixaban, and edoxaban
Design
Review
Authors
Discussion
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Member takes
Implication
Supports assay-specific DOAC monitoring; leaves open prospective outcome validation.
Structured PICO
What are the consensus guidelines and recommendations for laboratory assessment of direct oral anticoagulants?
P
Population
Patients taking direct oral anticoagulants (DOACs) including dabigatran, rivaroxaban, apixaban, and edoxaban
I
Intervention
Laboratory assessment and monitoring of DOAC effects and levels
O
Outcome
Concordance of published guidelines and recommendations for laboratory assessment of DOACs
This review clarifies the specific laboratory assays recommended for screening and quantifying the effects of different DOACs, challenging the dogma that they do not require monitoring.
Limitations
- Insufficient data for other direct anti-FXa agents
- Limited guidance in the literature
Cite This Study
Lippi et al. (2014) studied this question.