Key result
LARP1 and LARP4 interact with cytoplasmic poly(A)-binding protein to protect and stabilize the mRNA 3' poly(A) tail.
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: 5'TOP: 5' terminal oligopyrimidine, LaM: La motif, LARP: La-related protein, LARP1: La-related protein 1, MLLE: mademoiselle, NTR: N-terminal region, PABP: cytoplasmic poly(A)-binding protein (PABPC1), Pol III: RNA polymerase III, PAM2: PABP-interacting motif 2, PB: processing body, RRM: RNA recognition motif, SG: stress granule.
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Mattijssen et al. (2021) studied this question. LARP1 and LARP4 interact with cytoplasmic poly(A)-binding protein to protect and stabilize the mRNA 3' poly(A) tail.
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