Key result
Transjunctional potentials gate a population of 160-pS gap junction channels in embryonic chick ventricular cell pairs, with steady-state conductance declining when voltages exceed +/- 30 mV.
Population
Paired myocytes after enzymatic dissociation of 7-day-old embryonic chick ventricles (n=7 cell pairs)
Design
Preclinical
Authors
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No immediate clinical implications for human arrhythmias; leaves open voltage gating relevance in mammalian cardiac development.
This study demonstrates that a population of 160-pS gap junction channels in embryonic chick ventricular myocytes is gated by transjunctional potentials.
Richard D. Veenstra (1990) studied Embryonic chick ventricles (n=7). Transjunctional voltage was evaluated on Macroscopic gap junctional conductance (Gj) dependence on transjunctional voltage (Vj). Transjunctional potentials gate a population of 160-pS gap junction channels in embryonic chick ventricular cell pairs, with steady-state conductance declining when voltages exceed +/- 30 mV.
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