What question did this study set out to answer?

The study aims to estimate the incidence of amyloid PET positivity and its associated cognitive and imaging characteristics in cognitively normal individuals.

October 18, 2013NeurologyOpen Access

Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity

View Full Paper

Ask AI

Bookmark

The study aims to estimate the incidence of amyloid PET positivity and its associated cognitive and imaging characteristics in cognitively normal individuals.
Analyzed 207 cognitively normal participants with serial imaging assessments including amyloid PET, FDG-PET, and MRI.
Compared 26 subjects who became incident amyloid-positive to 69 stable amyloid-negative individuals.
Included 12 subjects with Alzheimer disease dementia for comparative analysis.
Incidence of amyloid PET positivity was approximately 13% per year among cognitively normal participants over age 70.
26 incident amyloid-positive subjects had a higher baseline task-free functional connectivity compared to stable amyloid-negative participants.
42% of incident amyloid-positive subjects exhibited evidence of neurodegeneration before becoming amyloid-positive.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Randomized trial estimates amyloid PET positivity incidence in cognitively normal individuals, suggesting dual biomarker pathways.

Cite This Study

Jack et al. (2013) studied this question.

synapsesocial.com/papers/6a22a427e4d98b33c2d2bde1 https://doi.org/10.1212/01.wnl.0000435556.21319.e4

View Full Paper

Ask AI

Bookmark

Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity

Key Points

Discussion

Implication

Cite This Study

Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider