Key result
IL-1 alpha treatment of primate bone marrow stromal cells transiently increased IL-11 mRNA levels by stabilizing the mRNA half-life, requiring RNA sequences from different regions of the IL-11 message.
Population
Primate bone marrow stromal cell line, PU-34
Design
Preclinical
Authors
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No immediate clinical implications from primate cell data; extends post-transcriptional IL-11 regulation insights but leaves translation open.
IL-1 alpha increases IL-11 expression in primate bone marrow stromal cells via mRNA stabilization requiring multiple RNA sequence regions.
Yang et al. (1994) studied this question. IL-1 alpha was evaluated on IL-11 mRNA steady state level and half-life. IL-1 alpha treatment of primate bone marrow stromal cells transiently increased IL-11 mRNA levels by stabilizing the mRNA half-life, requiring RNA sequences from different regions of the IL-11 message.
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