Answers are grounded in this paper and cite their sources.
This review summarizes the pathophysiological role of TNF-α in myocardial infarction and the potential of TNF-α antagonists as a therapeutic strategy.
Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches also investigated TNF-α antagonists and their potential therapeutic role in the setting of MI and heart failure at both molecular and clinical level. This article briefly reviews TNF-α and its mechanism as a mediator in MI.
No takes yet. Share an insight, caveat, or question.
Tian et al. (2015) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: