Key result
A novel bi-modal probe integrating A-scan ultrasound and a force sensor reliably recorded simultaneous pressure and diameter signals with an SNR of 20 dB to construct arterial PD loops.
Why the study?
Existing methodologies often fail to account for potential errors in arterial pressure and diameter measurements when assessing cardiovascular mechanical properties.
A novel bi-modal probe combining A-scan ultrasound and a force sensor successfully enables simultaneous, single-site measurement of arterial pressure-diameter loops with high signal-to-noise ratio.
May enable integrated arterial mechanics assessment; leaves open clinical validation and outcome studies.
There is an ever-increasing interest in the research community towards the development of advanced in-vivo diagnostic and screening tools for cardiovascular diseases. Various methodologies often do not account for potential errors in arterial pressure and diameter measurements. This paper highlights these pitfalls through the design and instrumentation of a bi-modal probe integrated with A-scan ultrasound and force sensor. This probe is used for simultaneous and single-site assessment of pressure – diameter (PD) loop of superficial arteries. In-vivo measurement of PD loop is a gateway to study the mechanical properties of artery, design and development of vascular grafts and clinically significant for measurement of arterial stiffness, local pulse wave velocity, and central blood pressure. The novelty comes with the usage of an image free A-scan mode of ultrasound, which makes it possible to keep the force sensor and ultrasound transducers very close, solving one of the challenges faced by state-of-the-art techniques in single site measurement. In addition to this, in-house-developed acquisition hardware and software ensures matched frequency response and time synchronization for both pressure and diameter signals. Signals were reliably recorded with an SNR of 20 dB and constructed PD loop is in the clockwise direction with pressure signals leading diameter signals.
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Manoj et al. (2020) studied Cardiovascular diseases. Bi-modal probe integrated with A-scan ultrasound and force sensor was evaluated on Signal-to-noise ratio (SNR) and construction of pressure-diameter (PD) loop. A novel bi-modal probe integrating A-scan ultrasound and a force sensor reliably recorded simultaneous pressure and diameter signals with an SNR of 20 dB to construct arterial PD loops.
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