Key result
Novel ultrasonic probe closely mirrors pressure sensor waveforms in radial artery measurements.
Why the study?
An evaluation index for vascular endothelial function based on simultaneous measurement of blood pressure and vessel diameter changes in the radial artery was needed.
Effect estimate: r = 0.979 - 0.999
A newly developed ultrasonic probe can simultaneously measure changes in blood pressure and diameter in the radial artery, allowing for the estimation of vascular viscoelasticity.
Supports probe utility for animal radial artery viscoelasticity; leaves open human validation and clinical translation.
To establish an evaluation index for vascular endothelial function, we developed an ultrasonic probe that can measure changes in blood pressure and blood vessel diameter at the same position in the radial artery. Based on phantom experiments, the pressure waveforms measured using the piezoelectric effect of the ultrasonic probe element and those using a pressure sensor exhibited a high correlation (correlation coefficient: r = 0.979 – 0.999). We confirmed the continuous measurement of the relationship between changes in blood pressure and the diameter from the in vivo experiments. We could then estimate the changes in viscoelasticity by calibrating the output from the probe element to the absolute blood pressure values in advance. The average coefficients of variations were 0.02 and 0.24 for elasticity and viscosity, respectively. This study demonstrated the possibility of measuring changes in the viscoelastic moduli of the radial arterial wall due to flow-mediated dilation using the developed ultrasonic probe.
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Saito et al. (2020) studied Vascular endothelial function evaluation. Ultrasonic probe for simultaneous measurement of pressure and diameter vs. Pressure sensor (in phantom experiments) was evaluated on Correlation of pressure waveforms between ultrasonic probe and pressure sensor (r = 0.979 - 0.999). A newly developed ultrasonic probe demonstrated high correlation with a pressure sensor (r = 0.979-0.999) in measuring radial artery pressure waveforms and estimating viscoelasticity.
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