Key result
Novel ultrasonic probe links rising diastolic BP to increased arterial elastic and viscosity moduli.
Why the study?
Noninvasive evaluation of arterial wall viscoelastic properties for early diagnosis of arteriosclerosis is limited by beat-to-beat pulse pressure variations when using conventional sphygmomanometry.
A newly developed ultrasonic probe and beat-by-beat blood pressure method can simultaneously measure blood pressure waveforms and vessel diameter changes to determine arterial viscoelastic properties, potentially aiding in early diagnosis of arteriosclerosis.
Answers are grounded in this paper and cite their sources.
Simultaneous pulse pressure and strain measurement may reduce beat-to-beat error in arterial modulus estimates; leaves open prospective validation for arteriosclerosis screening.
We have been studying a method for noninvasively evaluating the viscoelastic properties of the arterial wall for early diagnosis of arteriosclerosis. The elastic modulus of the arterial wall is determined by the ratio of the pulse pressure to the caused pulsatile strain. Conventionally, pulse pressure is measured with a sphygmomanometer before or after ultrasonic strain measurement. However, the pulse pressure changes from beat to beat, resulting in a significant error in the elastic modulus. Therefore, a beat-by-beat blood pressure method was newly introduced based on the simultaneous measurement of pulse wave velocity and change in arterial diameter to improve the reproducibility of the elastic modulus. Moreover, a new ultrasonic probe was developed to simultaneously measure the blood pressure waveforms and changes in vessel diameter at the same position. The hysteresis curve between blood pressure and arterial diameter obtained with this ultrasonic probe enabled us to determine both the elastic and viscosity moduli. They were measured at different diastolic blood pressures at the radial artery, both of which increased with increasing blood pressure. This method has the potential to sensitively detect minute changes in arterial wall properties during arteriosclerosis progression.
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荒川元孝 et al. (2025) studied this question. A novel ultrasonic probe simultaneously measuring blood pressure and arterial diameter determined elastic and viscosity moduli, both of which increased with rising diastolic blood pressure.
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