Key result
Estimated elasticity and viscosity of the arterial wall increased with internal pressure, indicating the benefit of measuring blood pressure alongside elastic and viscous moduli.
Why the study?
Because vascular wall elasticity depends on blood pressure, the authors sought to estimate arterial elasticity and viscosity by altering internal pressure in phantom and in vivo experiments.
Measuring both blood pressure and elastic/viscous moduli via ultrasound may help comprehensively investigate vessel wall properties changing with arteriosclerosis progression.
Pressure dependence of wall properties in animals supports combined BP-moduli measurement; leaves open human translation for arteriosclerosis assessment.
Previously, we proposed an ultrasonic measurement method of arterial wall elasticity for the early detection of arteriosclerosis. Since vascular wall elasticity depends on blood pressure, in this study, the elasticity and viscosity were estimated using the hysteresis loop determined between the incremental strain in the wall and internal pressure by altering the internal pressure in the phantom and in vivo experiments. Consequently, both the estimated elasticity and viscosity increased with the internal pressure. Moreover, the slope of each hysteresis loop was larger than that of the approximated curve for the lowest blood pressures of the hysteresis loops with different internal pressures, as the blood pressure changed in the order of several hertz within a single heartbeat. Hence, we conclude that measuring both the blood pressure and the elastic and viscous moduli would be beneficial in comprehensively investigating more vessel wall properties that change with the progression of arteriosclerosis.
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Suzuki et al. (2023) studied Arteriosclerosis. Ultrasonic measurement of arterial wall elasticity and viscosity was evaluated on Elasticity and viscosity dependence on internal pressure. Estimated elasticity and viscosity of the arterial wall increased with internal pressure, indicating the benefit of measuring blood pressure alongside elastic and viscous moduli.
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