Key result
The multifactorial nature of smooth muscle cell growth control and diverse cell populations may explain the regional heterogeneity of arterial structural changes in hypertension and restenosis.
Proposes hypotheses to explain the regional heterogeneity of arterial structural changes in hypertension and restenosis based on smooth muscle cell population diversity.
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Heterogeneity in arterial remodeling cautions against uniform therapies; leaves open validation of smooth muscle cell subpopulations in prospective studies.
Arterial structural changes in experimental models of hypertension and restenosis differ between vessel types and within vessels. Inspired by the diversity of short-term functional responses to vasoactive agents, hypotheses are presented with respect to the heterogeneity of structural alterations. Considered are the multifactorial nature of smooth muscle cell growth control and the possibility that vascular smooth muscle is not homogeneous but composed of different smooth muscle cell populations. These hypotheses may help explain the origin of both intervascular and intravascular heterogeneity of vascular structural responses.
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Daemen et al. (1995) conducted a review in Hypertension and restenosis (experimental models). Arterial structural changes was evaluated. The multifactorial nature of smooth muscle cell growth control and diverse cell populations may explain the regional heterogeneity of arterial structural changes in hypertension and restenosis.
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