Key result
Treatment with NSAIDs in patients with acute myocarditis was not associated with a worse outcome (p=0.115), differences in left ventricular systolic function (p=0.228), or complications (p=0.507).
Why the study?
Animal studies linked NSAIDs to adverse outcomes in acute myocarditis, leading to recommendations against their use, but clinical evidence on their effects in patients remained needed.
Does NSAID treatment worsen outcomes in patients with acute myocarditis or myopericarditis?
Population
114 patients with acute myocarditis
Comparison
NSAID treatment vs controls
Design
Retrospective case-control study with propensity score matching
Follow-up
Two years
Authors
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NSAIDs were not linked to worse outcomes in acute myocarditis; leaves open safety and efficacy pending randomized trials.
Case-Control (n=114)
Does NSAID treatment worsen outcomes in patients with acute myocarditis or myopericarditis?
p-value: p=0.115
In a retrospective case-control study, NSAID use in acute myocarditis was not associated with increased mortality or worse left ventricular function, suggesting they may be safe despite current recommendations.
Mirna et al. (2022) conducted a case-control in Acute myocarditis and myopericarditis (n=114). Non-steroidal anti-inflammatory drugs (NSAIDs) vs. Controls (no NSAIDs) was evaluated on All-cause mortality / worse outcome (p=0.115). Treatment with NSAIDs in patients with acute myocarditis was not associated with a worse outcome (p=0.115), differences in left ventricular systolic function (p=0.228), or complications (p=0.507).
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