Why the study?
Does measurement of cardiac troponin I (cTnI) improve the detection of myocyte injury in myocarditis compared to CK-MB?
Population
88 patients referred to the Myocarditis Treatment Trial and a preclinical model of 26 mice with autoimmune…
Comparison
Measurement of serum cardiac troponin I (cTnI) vs Measurement of creatine kinase-MB (CK-MB)
Design
Cohort
Key result
Cardiac troponin I was elevated in 34% of patients with biopsy-proven myocarditis compared to 5.7% for CK-MB (P=0.001), demonstrating superiority for detecting myocyte injury.
Authors
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cTnI may aid myocarditis injury detection over CK-MB; leaves open whether it improves diagnosis or outcomes in prospective studies.
Observational (n=88)
Does measurement of cardiac troponin I (cTnI) improve the detection of myocyte injury in myocarditis compared to CK-MB?
Absolute Event Rate: 34% vs 5.7%
p-value: p=.001
Cardiac troponin I is superior to CK-MB for detecting myocyte injury in myocarditis, with elevations most common within the first month of heart failure symptom onset.
Smith et al. (1997) conducted an observational in Myocarditis (n=88). Cardiac troponin I (cTnI) vs. Creatine kinase-MB (CK-MB) was evaluated on Elevation of serum marker in patients with biopsy-proven myocarditis (p=.001). Cardiac troponin I was elevated in 34% of patients with biopsy-proven myocarditis compared to 5.7% for CK-MB (P=0.001), demonstrating superiority for detecting myocyte injury.