Key result
Procaine amide exerted a complex action on cardiac excitability in sheep Purkinje fibers by decreasing membrane conductance, primarily sodium conductance.
Why the study?
Does procaine amide alter excitability and membrane properties in mammalian cardiac Purkinje fibers?
Population
Long sheep Purkinje fibers in normal Tyrode's solution with [K+]0 = 4.0 mM
Design
Preclinical
Authors
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May explain procaine amide's dual antiarrhythmic effects; hypothesis-generating for human translation.
Does procaine amide alter excitability and membrane properties in mammalian cardiac Purkinje fibers?
Procaine amide exerts complex effects on cardiac excitability by decreasing membrane sodium conductance, providing a mechanistic explanation for its dual antiarrhythmic and arrhythmogenic clinical profile.
Arnsdorf et al. (1976) studied this question. Procaine amide was evaluated on Cardiac excitability (strength-duration and charge-duration curves, membrane characteristics, and cable properties). Procaine amide exerted a complex action on cardiac excitability in sheep Purkinje fibers by decreasing membrane conductance, primarily sodium conductance.
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