Key result
Testosterone treatment in male rats with heart failure significantly reduced mortality compared to placebo (31.8% vs 68.2%, P<0.05) and improved cardiac function.
Why the study?
Does testosterone improve cytokines and ventricular remodeling in male rats with heart failure?
RCT (n=59)
Does testosterone improve cytokines and ventricular remodeling in male rats with heart failure?
Absolute Event Rate: 31.8% vs 68.2%
p-value: p=<0.05
In a rat model of heart failure, testosterone treatment improved cardiac function, reduced adverse remodeling, and decreased mortality.
Testosterone may benefit experimental HF in rats but should not change practice; leaves open translation to humans.
AIMS: To investigate the effects of testosterone treatment on cytokines, ventricular remodeling in rats with heart failure. MATERIALS AND METHODS: Sprague-Dawley male rats with heart failure were divided into testosterone (n = 22) and placebo (n = 22) group. Pseudo surgery was performed on a third group of 15 male rats as control. RESULTS: Compared with the placebo group, the testosterone group had a greater LVEF (P <0.05), a higher serum IL-10 level (P <0.05) and a lower serum TNF-alpha level (P<0.05). The expression of TNF-alpha mRNA, MMP-9 mRNA and the myocardial hydroxyproline contents in the testosterone group were also lower than in the placebo group (P<0.05). The mortality rate in the testosterone and placebo group was 31.8% and 68.2%, respectively (P <0.05). CONCLUSION: Serum testosterone levels were decreased significantly in male rats with heart failure. Testosterone treatment diminishes the imbalance between interleukin-10 and TNF-alpha, suppresses ventricular remodeling and improves cardiac function.
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Zhang et al. (2007) conducted an RCT in Heart failure (n=59). Testosterone vs. Placebo was evaluated on Mortality rate (p=<0.05). Testosterone treatment in male rats with heart failure significantly reduced mortality compared to placebo (31.8% vs 68.2%, P<0.05) and improved cardiac function.
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