Key result
The LVOT/AO diameter ratio measured by CMR accurately detected a resting LVOT gradient >30 mmHg with an area under the ROC curve of 0.91 (95% CI 0.85-0.97).
Why the study?
Does the LVOT/AO diameter ratio measured by CMR accurately predict the severity of LVOT obstruction in patients with hypertrophic cardiomyopathy compared to Doppler echocardiography?
Observational (n=92)
Does the LVOT/AO diameter ratio measured by CMR accurately predict the severity of LVOT obstruction in patients with hypertrophic cardiomyopathy compared to Doppler echocardiography?
Effect estimate: AUC 0.91 (95% CI 0.85-0.97)
The LVOT/AO diameter ratio measured by CMR is a highly accurate and noninvasive surrogate marker for detecting clinically significant LVOT obstruction in patients with hypertrophic cardiomyopathy.
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May support CMR LVOT/AO ratio as noninvasive marker of obstruction severity in HCM; hypothesis-generating pending prospective validation.
Vogel‐Claussen et al. (2012) conducted an observational in Hypertrophic cardiomyopathy (HCM) (n=92). LVOT/AO diameter ratio measured by cardiac magnetic resonance (CMR) vs. Doppler echocardiography was evaluated on Detection of a resting gradient >30 mmHg (AUC 0.91, 95% CI 0.85-0.97). The LVOT/AO diameter ratio measured by CMR accurately detected a resting LVOT gradient >30 mmHg with an area under the ROC curve of 0.91 (95% CI 0.85-0.97).
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