Discordance among Commercially Available Diagnostics for Latent Tuberculosis Infection

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This study aims to evaluate differences among tests for latent tuberculosis infection and their interpretations in a low-prevalence setting.
Cross-sectional comparison study of 2,017 military recruits at Fort Jackson, South Carolina.
Simultaneous testing with QuantiFERON-TB Gold, T-SPOT.TB, tuberculin skin test, and Battey skin test was conducted.
Risk factor questionnaire included evaluating Bacille Calmette-Guérin vaccination and country of birth.
Out of 88 positive tests, only 10 (11.4%) were positive on all three tests; 20 (22.7%) were positive on at least two tests.
Specificities of the three diagnostic tests did not show significant differences.
False-positive results were primarily attributed to nontuberculous mycobacteria reactivity and Bacille Calmette-Guérin vaccination.

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Cross-sectional comparison assesses test discordance in a low-prevalence population, indicating false-positives may predominate.

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Mancuso et al. (2011) studied this question.

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