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September 1, 1986Journal of Experimental Biology

Properties And Modulation of Cardiac Calcium Channels

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Key result

Isoproterenol and 8-bromo-cAMP increased the overall open state probability of individual calcium channels in rat heart myocytes, while single channel currents remained unaffected.

Population

Myocytes from rat hearts

Comparison

Isoproterenol, 8-bromo-cAMP, or… vs Absence of isoproterenol or 8-bromo-cAMP

Design

Preclinical

Authors

HRH. RéuterUniversity of CologneSKShinichiro KokubunNihon UniversityBPBlaise Prod'homBoston University

Discussion

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Implication

Provides mechanistic basis for beta-adrenergic ICa effects in rat myocytes; leaves open relevance to human cardiac disease and therapy.

Structured PICO

P
Population
Myocytes from rat hearts
I
Intervention
Isoproterenol, 8-bromo-cAMP, or 1,4-dihydropyridines
C
Comparator
Absence of isoproterenol or 8-bromo-cAMP
O
Outcome
Single calcium channel currents and gating kinetics (open state probability, mean open times, burst length)surrogate

Beta-adrenergic stimulation increases macroscopic cardiac calcium currents by increasing the open state probability of individual L-type calcium channels via cAMP-dependent phosphorylation.

Cite This Study

Réuter et al. (1986) studied this question. Isoproterenol and 8-bromo-cAMP vs. Absence of compounds was evaluated on Calcium channel open state probability (po) and single channel currents (i). Isoproterenol and 8-bromo-cAMP increased the overall open state probability of individual calcium channels in rat heart myocytes, while single channel currents remained unaffected.

synapsesocial.com/papers/6a22ba5454bc213887d2e4b5https://doi.org/10.1242/jeb.124.1.191
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of Calcium Channels in Cultured Cardiac Cells by Isoproterenol and 8-Bromo-cAMP1983 · 38 citations
  2. 2Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.1985 · 719 citations
  3. 3Mechanisms of calcium channel modulation by β-adrenergic agents and dihydropyridine calcium agonists1986 · 498 citations
  4. 4Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells.1984 · 322 citations
  5. 5Two types of calcium channels in the somatic membrane of new‐born rat dorsal root ganglion neurones.1985 · 408 citations