Key result
Shear wave elastography reliably measures carotid stiffness, optimized by 1-mm posterior wall sampling.
Why the study?
Carotid artery stiffness is associated with aging and atherosclerosis leading to cerebrovascular events, but the technical feasibility of shear wave elastography to directly measure it required validation.
Observational (n=10)
No
Shear Wave Elastography is a technically feasible, non-invasive ultrasound modality for directly assessing carotid artery stiffness, though standardization of technique is required to overcome artifacts from arterial wall motion.
Supports feasibility of carotid shear wave elastography; leaves open standardization and validation before clinical adoption.
Carotid artery stiffness is associated with aging and atherosclerotic disease, leading to cerebrovascular events. Shear Wave Elastography (SWE) is a novel ultrasound technique offering a direct, quantitative assessment of the arterial wall elasticity. The aim of this study is to validate the technical feasibility of SWE in measuring carotid stiffness (CS). A literature search was performed across the PubMed and Scopus databases, with keywords including "carotid stiffness", "Shear Wave Elastography", "atherosclerosis", and "vascular elasticity". The findings reveal the potential of SWE in quantifying carotid Intima-Media Complex (IMC) stiffness, with implications for the early diagnosis of vascular disease, aiding in clinical decision making and prognostic assessment. Based on the findings of the literature search, a small pilot study was conducted involving 10 participants, using the Philips EPIQ Elite system for the SWE measurements. The technical analysis revealed optimizing the region of interest (ROI) size, probe positioning, and cine-loop analysis as crucial factors for obtaining accurate results. The results of the literature review and small pilot study demonstrate the potential of SWE as a non-invasive method for assessing carotid stiffness. Certain technical adjustments, such as smaller ROIs and careful probe placement, improved the accuracy and repeatability of carotid SWE measurements. Further studies are needed to assess and standardize carotid SWE across larger patient populations.
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Kavvadas et al. (2025) conducted an observational in Healthy volunteers (feasibility of carotid stiffness measurement) (n=10). Shear Wave Elastography (SWE) was evaluated on Feasibility and reproducibility of carotid stiffness measurement. Shear Wave Elastography demonstrated feasibility for assessing carotid stiffness in a pilot study, with optimized accuracy achieved by using 1 mm regions of interest on the posterior arterial wall.
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