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October 1, 2002Journal of Cardiovascular Pharmacology

Lower Risk of Postinfarct Rupture in Mouse Heart Overexpressing β2-Adrenergic Receptors: Importance of Collagen Content

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Key result

Transgenic mice overexpressing beta2-adrenergic receptors had a significantly lower incidence of LV rupture compared to wild-type mice (2.5% vs 19.7%, p<0.05) 3-5 days after myocardial infarction.

Why the study?

Does overexpression of beta2-adrenergic receptors reduce the incidence of left ventricular rupture after myocardial infarction in mice?

Population

Transgenic mice overexpressing beta2-adrenergic receptor in the heart and wild-type mice undergoing left…

Comparison

Overexpression of beta2-adrenergic receptor vs Wild-type mice

Design

Preclinical

Follow-up

1-7 days

Authors

XGXiao-Ming GaoBaker Heart and Diabetes InstituteRDRodney J. DilleyThe University of Western AustraliaCSChrishan S. SamuelDiscovery Institute

Discussion

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Member takes

Overview

Supports beta2 signaling in post-MI healing in mice; leaves open clinical translation.

Key Points

  • To determine the impact of beta-adrenergic receptor overexpression on the risk of left ventricular rupture post-myocardial infarct in mice.
  • Transgenic and wild-type mice underwent left coronary artery occlusion.
  • Incidence of postinfarct deaths was analyzed from 1-7 days after surgery.
  • Hemodynamics and morphologic parameters, including collagen content, were assessed.
  • Transgenic mice showed a 2.5% incidence of LV rupture compared to 19.7% in wild-type mice (p < 0.05).
  • Collagen content in transgenic mice was significantly higher than in wild-type (p < 0.01).
  • Despite higher left ventricular contractility, transgenic mice had a lower risk of rupture post-infarct.

Structured PICO

Does overexpression of beta2-adrenergic receptors reduce the incidence of left ventricular rupture after myocardial infarction in mice?

P
Population
Transgenic mice overexpressing beta2-adrenergic receptors and wild-type mice undergoing left coronary artery occlusion, followed for 1-7 days post-infarct.
E
Exposure
Overexpression of beta2-adrenergic receptor
C
Comparator
Wild-type mice
O
Outcome
Incidence of left ventricular rupture 1-7 days after myocardial infarcthard clinical

Main Result

Absolute Event Rate: 2.5% vs 19.7%

p-value: p=< 0.05

Overexpression of beta2-adrenergic receptors in mice reduces the risk of post-infarct cardiac rupture, suggesting interstitial collagen levels are more critical than functional status in rupture pathogenesis.

Cite This Study

Gao et al. (2002) studied Myocardial infarct. Overexpression of beta2-adrenergic receptors vs. Wild-type mice was evaluated on Incidence of LV rupture 3-5 days after myocardial infarct (p=< 0.05). Transgenic mice overexpressing beta2-adrenergic receptors had a significantly lower incidence of LV rupture compared to wild-type mice (2.5% vs 19.7%, p<0.05) 3-5 days after myocardial infarction.

synapsesocial.com/papers/6a22bb1029c8bdba62cd668chttps://doi.org/10.1097/00005344-200210000-00018
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor1994 · 745 citations
  2. 2Role of collagen in acute myocardial infarct expansion.1991 · 179 citations
  3. 3Regulation of procollagen metabolism in the pressure-overloaded rat heart.1993 · 58 citations
  4. 4Early and Delayed Consequences of β 2 -Adrenergic Receptor Overexpression in Mouse Hearts2000 · 397 citations
  5. 5Altered cardiac collagen and associated changes in diastolic function of infarcted rat hearts2000 · 36 citations