Key result
Over a 10-year period, MOF-related mortality decreased in emergency non-cardiac surgical ICU patients with (IRR 0.972; 95% CI 0.948-0.996) and without (IRR 0.957; 95% CI 0.931-0.983) CNS failure.
Why the study?
Epidemiologic data regarding independent predictors, incidence, and mortality of multiple organ failure have changed over past decades, prompting an assessment of potential changes in its incidence, outcomes, and resource utilization over a 10-year period.
Population
13,270 adult emergency non-cardiac surgery ICU admissions
Comparison
MOF with vs without CNS failure, and early-onset vs late-onset MOF over time
Design
10-year retrospective observational study
Authors
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Declining early MOF mortality in emergency non-cardiac surgical ICU patients may reflect care advances; leaves open targeted strategies for persistent late-onset MOF.
Observational (n=13,270)
Relative Risk: 0.972 (95% CI 0.948–0.996)
p-value: p=0.022
Over a 10-year period, the incidence and mortality of early-onset multiple organ failure in emergency non-cardiac surgical ICU admissions decreased, while late-onset MOF remained constant.
Jansson et al. (2021) conducted an observational in Multiple organ failure in emergency non-cardiac surgical admissions (n=13,270). Time period (2008-2017) was evaluated on MOF-related mortality with CNS failure (IRR 0.972, 95% CI 0.948-0.996, p=0.022). Over a 10-year period, MOF-related mortality decreased in emergency non-cardiac surgical ICU patients with (IRR 0.972; 95% CI 0.948-0.996) and without (IRR 0.957; 95% CI 0.931-0.983) CNS failure.
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