Key result
Invasive AMI management linked to ~29% lower mortality in older adults with dementia.
Why the study?
AMI management strategies involving treatment and post-care are more difficult for patients with dementia, prompting an investigation into factors influencing invasive procedure use, long-term care, and survival.
Does the use of invasive management procedures and long-term care improve survival in older adults with dementia and acute myocardial infarction?
Cohort (n=13,593)
Does the use of invasive management procedures and long-term care improve survival in older adults with dementia and acute myocardial infarction?
Hazard Ratio: 0.71 (95% CI 0.66–0.77)
Invasive management procedures and long-term care are associated with improved survival in older patients with dementia suffering from acute myocardial infarction, though older age and female sex are associated with lower utilization of invasive treatments.
May support invasive AMI management in select dementia patients; leaves open causal confirmation in randomized trials.
BACKGROUND: Acute myocardial infarction (AMI) management strategies, involving treatment and post-care, are much more difficult for patients with dementia. This study investigated the factors influencing the use of invasive procedures and long-term care in the management strategies for AMI patients with dementia and the factors associated with these patients' survival. METHODS: This multilevel study combined information from two databases, namely later-stage elderly healthcare insurance and long-term care insurance claims, from 2013 to 2019. Of 214,963 individuals with dementia, we identified 13,593 patients with AMI. The primary outcomes were the use of invasive procedures for treatment and long-term care for post-care management. Survival outcomes were also measured over a 6-year period, adjusting for individual- and regional-level characteristics in multilevel models. RESULTS: A total of 1954 (14.38%) individuals received an invasive procedure during treatment, and 7850 (87.18%) used long-term care for post-care management after AMI. After multivariate adjustment, patients aged ≥ 85 years and women were less likely to receive invasive procedures and more likely to use long-term care. Patients undergoing invasive procedures had a lower use of long-term care. Better survival outcome was significantly associated with invasive management and long-term care, regardless of the type of care. CONCLUSION: Age and sex determine the use of invasive procedures and long-term care after AMI among patients with dementia. AMI patients with dementia receiving invasive procedures and long-term care had better survival outcomes.
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Li et al. (2021) conducted a cohort in Acute myocardial infarction in older adults with dementia (n=13,593). Invasive management procedures (PCI or CABG) vs. No invasive management procedures was evaluated on Survival outcome (hazard of death) (HR 0.71, 95% CI 0.66-0.77). Invasive management procedures for acute myocardial infarction in older adults with dementia were associated with a significantly lower hazard of death compared to no invasive procedures (HR 0.71, 95% CI 0.66-0.77).
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