Key result
Recent findings highlight the roles of lysine-specific demethylase 1, caveolin 1, and striatin as new mediators of aldosterone's mechanisms of action in cardiovascular pathophysiology.
Recent findings identify LSD1, cav-1, and striatin as novel mediators of aldosterone's genomic and nongenomic effects in the cardiovascular system.
These mediators remain hypothesis-generating; leaves open their therapeutic targeting in salt-sensitive hypertension pending validation studies.
PURPOSE OF REVIEW: Aldosterone's functions and mechanisms of action are different depending on the tissue and the environmental condition. The mineralocorticoid receptor is present in tissues beyond epithelial cells, including the heart and vessels. Furthermore, aldosterone has direct adverse effects by both genomic and rapid/nongenomic actions not only through a nuclear receptor but also through caveolae-mediated intracellular events. Also, multiple environmental-genetic interactions play an important role in salt-sensitive hypertension (SSH) and aldosterone modulation. These findings have reshaped our vision of aldosterone's role in cardiovascular pathophysiology. This review describes new mediators of aldosterone's mechanisms of action: lysine-specific demethylase 1 (LSD1), caveolin 1 (cav-1) and striatin. RECENT FINDINGS: LSD1, an epigenetic regulator, is involved in the pathogenesis of SSH in both humans and rodents. In addition, cav-1, the main component of caveolae, plays a substantial role in mediating aldosterone pathways of SSH. The mineralocorticoid receptor interacts with cav-1 and is modulated by sodium intake. Finally, striatin, a scaffolding protein, mediates a novel interaction between signalling molecules and mineralocorticoid receptor's rapid effects in the cardiovascular system. SUMMARY: Substantial progress in aldosterone's functions and mechanisms of action should facilitate the study of cardiovascular diseases and the role of sodium intake in aldosterone-induced damage.
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Baudrand et al. (2013) conducted a review in Salt-sensitive hypertension and cardiovascular pathophysiology. Aldosterone mechanisms was evaluated. Recent findings highlight the roles of lysine-specific demethylase 1, caveolin 1, and striatin as new mediators of aldosterone's mechanisms of action in cardiovascular pathophysiology.
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