Key result
Increased admission levels of MCSF were strongly and independently associated with an eventful in-hospital outcome in patients with severe unstable angina (OR 3.3; 95% CI 1-10.9; p=0.04).
Why the study?
Do admission levels of CRP, fibrinogen, IL-6, and MCSF predict short-term in-hospital prognosis in patients with severe unstable angina?
Observational (n=141)
Do admission levels of CRP, fibrinogen, IL-6, and MCSF predict short-term in-hospital prognosis in patients with severe unstable angina?
Among inflammatory indices, only increased admission levels of MCSF are strongly and independently related to adverse short-term prognosis in severe unstable angina.
MCSF may aid short-term risk stratification in unstable angina but should not yet change practice; leaves open validation and therapeutic targeting.
BACKGROUND: Inflammatory process plays an important role in the pathogenesis of acute coronary syndromes. HYPOTHESIS: The study was undertaken to evaluate whether admission levels of C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6). and macrophage colony stimulating factor (MCSF) can predict short-term prognosis in patients with unstable angina. METHODS: C-reactive protein, fibrinogen, IL-6, and MCSF were measured on admission in 141 consecutive patients, aged 59 +/- 10 years, with unstable angina (Braunwald class IIIb). Patients were divided into two groups according to their in-hospital outcome: Group 1 comprised 77 patients with a complicated course (2 died, 15 developed nonfatal myocardial infarction, and 60 had recurrence of angina), and Group 2 comprised 64 patients with an uneventful course. RESULTS: Admission median levels of CRP (8.8 vs. 3.1 mg/l, p = 0.0002). fibrinogen (392 vs. 340 mg/dl, p = 0.008), IL-6 (8.8 vs. 4.5 pg/ml, p = 0.03), and MCSF (434 vs. 307 pg/ml, p = 0.0001) were higher in Group I than in Group 2. The MCSF levels were an independent risk factor for in-hospital events, with an adjusted odds ratio for eventful in-hospital outcome of 3.3 (95% confidence interval 1-10.9, p = 0.04), and correlated with levels of IL-6 (r(s) = 0.52, p = 0.0001), CRP (r(s) = 0.43, p = 0.0001), and fibrinogen (r(s) = 0.25, p = 0.004). CONCLUSIONS: These findings suggest that among the studied inflammatory indices only increased admission levels of MCSF are strongly and independently related with adverse short-term prognosis in patients with severe unstable angina.
No takes yet. Share an insight, caveat, or question.
Rallidis et al. (2002) conducted an observational in Severe unstable angina (n=141). Macrophage colony stimulating factor (MCSF) was evaluated on Eventful in-hospital outcome (death, nonfatal myocardial infarction, or recurrence of angina) (OR 3.3, 95% CI 1-10.9, p=0.04). Increased admission levels of MCSF were strongly and independently associated with an eventful in-hospital outcome in patients with severe unstable angina (OR 3.3; 95% CI 1-10.9; p=0.04).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: