Key result
Elevated levels of Hs-CRP (3.57 vs 0.81 mg/l, p<0.001) and fibrinogen (588.6 vs 356.9 mg/dl, p<0.001) at admission were significantly associated with adverse hospital outcomes in unstable angina.
Why the study?
Do elevated levels of Hs-CRP and Fibrinogen at admission predict adverse hospital outcomes in patients with unstable angina?
Observational (n=50)
Open-label
No
Do elevated levels of Hs-CRP and Fibrinogen at admission predict adverse hospital outcomes in patients with unstable angina?
p-value: p=<0.001
Elevated levels of Hs-CRP and fibrinogen at admission are associated with adverse hospital outcomes in patients with unstable angina.
May aid risk stratification in unstable angina; leaves open therapeutic implications pending prospective trials.
Background: Unstable angina constitutes a clinical syndrome that is usually caused by atherosclerotic coronary artery disease and is associated with an increased risk of cardiac death and myocardial infarction. Material and Methods: An open, prospective, observational, comparative study was conducted. The study included 50 cases in age group 20-80 years admitted in Government Medical College, Amritsar diagnosed as unstable angina ruled out by Trop T and CPK-MB at admission. Hs-CRP and Fibrinogen levels were estimated at time of admission and repeated after 48 hours. Results: There was significant difference in the mean value of Hs-CRP between favourable and unfavourable group at the time of admission (0.807±0.37mg/l v/s 3.57±1.70mg/l, p<0.001). A significant difference in the mean value of Hs-CRP was found between favourable and unfavourable group after 48 hours (0.51±0.22mg/l v/s 4.03±1.84mg/l, p<0.001) There was significant difference in the mean value of fibrinogen between favourable and unfavourable group at the time of admission (356.94±72.50mg/dl v/s 588.60±94.89mg/dl, p<0.001). A significant difference in the mean value of fibrinogen was found between favourable and unfavourable group after 48 hours (309.11±75.25mg/dl v/s 622.60±133.42mg/dl, p<0.001). Conclusion: It is concluded that in patients with unstable angina, elevated levels of Hs-CRP and Fibrinogen at admission indicate an adverse hospital outcome.
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Singh et al. (2018) conducted an observational in Unstable angina (n=50). Elevated Hs-CRP and Fibrinogen levels vs. Lower Hs-CRP and Fibrinogen levels was evaluated on Adverse hospital outcome (p=<0.001). Elevated levels of Hs-CRP (3.57 vs 0.81 mg/l, p<0.001) and fibrinogen (588.6 vs 356.9 mg/dl, p<0.001) at admission were significantly associated with adverse hospital outcomes in unstable angina.
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