Plasma ANP levels positively correlated with left ventricular mass index, whereas plasma BNP levels were specifically increased in patients with concentric hypertrophy.
Cross-Sectional (n=84)
Do plasma BNP and ANP levels reflect left ventricular geometry and function in patients with mild to moderate essential hypertension?
Plasma BNP levels are elevated in hypertensive patients with concentric hypertrophy, suggesting it reflects LV overload or diastolic dysfunction.
We investigated whether plasma brain and atrial natriuretic peptide (BNP and ANP, respectively) levels could reflect left ventricular (LV) geometry and function in patients with mild to moderate essential hypertension. A positive correlation was found between LV mass index (LVMI) and plasma ANP levels in 84 untreated, hypertensive patients, but not between LVMI and plasma BNP levels. As compared with other geometric patterns, plasma BNP levels were increased in concentric hypertrophy, in which LVMI was increased and LV diastolic function was decreased. These data suggest that production of BNP was increased in hypertensive patients with concentric hypertrophy via LV overload or depression of diastolic function.
Kotaro Yasumoto (Wed,) conducted a cross-sectional in Mild to moderate essential hypertension (n=84). Plasma brain and atrial natriuretic peptide (BNP and ANP) levels vs. Other left ventricular geometric patterns was evaluated on Correlation with left ventricular mass index (LVMI) and geometric patterns. Plasma ANP levels positively correlated with left ventricular mass index, whereas plasma BNP levels were specifically increased in patients with concentric hypertrophy.