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Background: Contemporary stroke rehabilitation protocols traditionally emphasise session frequency and treatment duration over intervention intensity-yet emerging evidence suggests we may be preparing patients for therapeutic marathons when their brains demand neuroplastic sprints. Across neuroscientific, behavioural, and clinical domains, convergent data indicate that repetition density, metabolic load, engagement, and temporal compression-not cumulative minutes-constitute the biologically meaningful drivers of neuroplastic and myoplastic adaptation. Objective: This Perspective re-examines current rehabilitation paradigms through an intensity-centred lens, synthesising mechanistic evidence, clinical trials, and cross-cultural implementation models to determine whether high-intensity paradigms can more efficiently exploit neuroplastic windows and muscle adaptation dynamics. Methods: Evidence was integrated from intensity-focused RCTs, high-repetition upper limb training, HIIT-based protocols, constrained-duration boot-camp models, and comparative observations from West-Cameroon intensive programmes. Mechanistic principles of threshold-dependent plasticity, critical timing windows, and therapeutic momentum were analysed alongside real-world feasibility data from low-resource systems. Results: Across studies and contexts, high-intensity protocols-4-6 h/day for 3-4 weeks-consistently produced functional gains equivalent or superior to those achieved through conventional 1-2 h sessions over 12-16 weeks. Both neural and peripheral muscle plasticity responded more robustly to concentrated stimulation than to prolonged low-density regimens. Family-integrated programmes amplified therapeutic density and sustained momentum, demonstrating that intensity can be achieved without advanced technology. Conclusion: Rehabilitation effectiveness depends less on session duration than on the biological potency of stimulation delivered per unit time. Intensity-centred models align more closely with known mechanisms of neuroplasticity and muscle adaptation, offering a more efficient, scalable, and context-responsive pathway to post-stroke recovery. Future research should formalise intensity indices, determine minimal effective thresholds, and evaluate phenotype-specific dosing strategies to support the evolution toward precision rehabilitation.
Ibrahim Npochinto Moumeni (Thu,) studied this question.