Key result
Insulin and muscle overloading increased Ser2448 phosphorylation in mTOR, whereas muscle unloading decreased it, suggesting a role in protein synthesis control during hypertrophy and atrophy.
Skeletal muscle atrophy and hypertrophy are associated with decreases and increases in mTOR Ser(2448) phosphorylation, respectively, suggesting its role in protein synthesis control.
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Supports mTOR Ser2448 as a hypertrophy/atrophy marker in rodents; leaves open human validation and therapeutic targeting.
Reynolds et al. (2002) studied this question. Insulin and muscle loading/unloading was evaluated on Ser2448 phosphorylation in mTOR. Insulin and muscle overloading increased Ser2448 phosphorylation in mTOR, whereas muscle unloading decreased it, suggesting a role in protein synthesis control during hypertrophy and atrophy.
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