Ventilation, respiratory frequency and alveolar gas pressures were measured during anoxia in seven men, alveolar pCO, being maintained at or above the normal level. A given degree of anoxia caused a significantly greater response at a higher level of pCO2 in all subjects. This contradicts Gray's hypothesis that respiratory stimuli do not interact. At the normal alveolar pCO2 our results agreed better with the predictions from FitzGerald's data than with those of Gray.
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Cormack et al. (1957) studied this question.
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