What question did this study set out to answer?

To determine whether the acute inflammatory and hypertensive response of the eye to iris laser irradiation depends on functional sensory innervation.

October 10, 1980Quarterly Journal of Experimental Physiology and Cognate Medical Sciences

Axon Reflex in Ocular Injury: Sensory Mediation of the Response of the Rabbit Eye to Laser Irradiation of the Iris

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Authors

JBJohn M. ButlerNational Institute of Standards and Technology WUW.G. UngerUniversity of London DCD.F. ColeCarleton University

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Implication

Experimental study reveals sensory denervation abolishes laser-induced miosis and ocular hypertension in rabbits, suggesting iris trauma responses are propagated by axon reflexes.

Key Points

To determine whether the acute inflammatory and hypertensive response of the eye to iris laser irradiation depends on functional sensory innervation.
Assessed rabbit eyes subjected to high-energy laser irradiation of the iris before and after diathermic coagulation of the epigasserian nerve tract.
Evaluated pupillary constriction (miosis), uveal vasodilation, intraocular pressure (IOP), and blood-aqueous barrier integrity across intervals ranging from 90 minutes to 4 days post-denervation.
Pupillary constriction and IOP elevation remained virtually unchanged at 90 minutes following sensory denervation.
Ocular injury responses progressively diminished over time, resulting in essentially no response to high-energy laser irradiation by day 4 in denervated eyes.
Findings indicate the acute response is mediated via sensory nerve endings through an axon reflex that releases inflammatory mediators and interacts with endogenous prostaglandins.

Cite This Study

Butler et al. (1980) studied this question.

synapsesocial.com/papers/6a887bb037a6b4982d07cc3f https://doi.org/10.1113/expphysiol.1980.sp002516

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Implication

Experimental study reveals sensory denervation abolishes laser-induced miosis and ocular hypertension in rabbits, suggesting iris trauma responses are propagated by axon reflexes.

Axon Reflex in Ocular Injury: Sensory Mediation of the Response of the Rabbit Eye to Laser Irradiation of the Iris

Discussion

Member takes

Implication

Key Points

Cite This Study

Axon Reflex in Ocular Injury: Sensory Mediation of the Response of the Rabbit Eye to Laser Irradiation of the Iris

Discussion

Member takes

Implication

Key Points

Cite This Study

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