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This research aims to systematically evaluate the retinal damage caused by 525 nm laser irradiation across different power densities.

Multimodal evaluation of 525 nm laser-induced retinal injury in rabbits: structural, functional and cytokine analyses

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This research aims to systematically evaluate the retinal damage caused by 525 nm laser irradiation across different power densities.
24 rabbits were exposed to laser irradiation at 0.5, 200, 500, and 1000 mW/cm².
Multimodal assessments including electroretinography (ERG), OCT/OCTA, histopathology, and cytokine analysis were conducted.
Exposure lasted 0.25 seconds with evaluations done at specified time points post-injury.
No visible damage observed at 0.5 mW/cm² laser exposure.
At 1000 mW/cm², severe retinal detachment was recorded within 1 day, leading to a retinal hole by day 14.
Cytokine analysis revealed ANG-1 upregulation at 500 and 1000 mW/cm² (p < 0.01) and VEGF-A downregulation at 500 mW/cm² (p < 0.05).

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Randomized trial assesses retinal damage from 525 nm laser in rabbits, indicating varying injury levels based on power density.

Guo et al. (2026) studied this question.

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