Development of a risk score for predicting the benefit versus harm of extending dual antiplatelet therapy beyond 6 months following percutaneous coronary intervention for stable coronary artery disease

Figures

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  Fig 1. Cohort selection process. Reasons for exclusion of patients from study: CABG = coronary artery bypass graft surgery, CVA = cerebrovascular accident, MB = major bleeding, MI = myocardial infarction, OAC = oral anticoagulation, PCI = percutaneous coronary intervention. Other abbreviations: SCAD = stable coronary artery disease, DAPT = dual antiplatelet therapy.

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  Fig 2. ROC curves for prediction models. ROC curves and c-statistics of the ischaemic (left) and bleeding (right) prediction models.

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  Fig 3. Calibration plots for the prediction models. Calibration plots of the ischaemia (left) and bleeding (right) prediction models, showing the predicted (blue bars) and observed (orange line and dots) rate of events stratified by the quartiles of the predicted risk.

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  Fig 4. Distribution of risk score values in the study cohort. Distribution of risk score values in the study cohort.

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  Fig 5. Kaplan-Meier curves for clinical outcomes according to predicted ARD stratum. Kaplan Meier curves for the overall mortality (top row), composite ischaemic endpoint (middle row), and bleeding (bottom row) of patients treated with shorter (6 months) vs. longer (6–12 months) DAPT, stratified by quartiles of the predicted ARD between ischemic and bleeding events–lower three quartiles (left column) and upper quartile (right column). DAPT = dual antiplatelet therapy, MB = major bleeding.

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  Fig 6. Kaplan-Meier curves for clinical outcomes according to simplified risk score stratum. Kaplan Meier curves for the overall mortality (top row), composite ischaemic endpoint (middle row), and bleeding (bottom row) of patients treated with shorter (6 months) vs. longer (6–12 months) DAPT, stratified by quartiles of the risk score–lower three quartiles (left column) and upper quartile (right column). DAPT = dual antiplatelet therapy.

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  Fig 7. Distribution of DAPT scores in the study cohort. Distribution of DAPT scores in the study cohort.