Key result
Implantation of an external restrictive elastic titanium nickelide sac showed satisfactory compatibility with ventricular myocardium without negative tissue response in an experimental dog model.
Why the study?
Does an external restrictive elastic sac made from titanium nickelide show satisfactory morphological compatibility with ventricular myocardium in dogs with experimental left ventricular aneurysm?
Does an external restrictive elastic sac made from titanium nickelide show satisfactory morphological compatibility with ventricular myocardium in dogs with experimental left ventricular aneurysm?
An external restrictive elastic sac made from titanium nickelide demonstrates satisfactory morphological compatibility with ventricular myocardium in a canine model of left ventricular aneurysm.
Answers are grounded in this paper and cite their sources.
Compatible with canine myocardium; leaves open translation to human ventricular restraint devices.
The objective of this study is a morphological evaluation of compatibility of ventricular myocardium with the device of our original construction for restriction of heart chambers dilatation. In the experiment the device made from titanium nickelide was implanted into 8 outbred dogs with the previously induced experimental model of left ventricular aneurism. The animals were excluded from the experiment in 1, 3 and 6 months after implantation of an external restrictive elastic sac. Histological preparations of myocardium samples, which were in an immediate contact with titanium nickelide fibers were the subjects for studying of general tissue response to the presence of an implanted device. No data evidencing negative effect of an external restrictive elastic titanium nickelide sac on ventricular myocardium have been found. It means that an implanted sac has a satisfactory compatibility with biological tissues just as like as any other implant made from titanium nickelide.
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Казаков et al. (2010) studied experimental model of left ventricular aneurism (n=8). external restrictive elastic sac made from titanium nickelide was evaluated on morphological evaluation of compatibility of ventricular myocardium with the device. Implantation of an external restrictive elastic titanium nickelide sac showed satisfactory compatibility with ventricular myocardium without negative tissue response in an experimental dog model.
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