This review provides an overview of the appropriate laboratory assays for monitoring NOACs and the specific antidotes currently in development to reverse their anticoagulant effects.
May guide NOAC assay selection and antidote awareness in bleeding; leaves open prospective validation before routine adoption.
In the last decade, we have witnessed the emergence of the oral non-vitamin K oral anticoagulants (NOACs), which have numerous advantages compared with the vitamin K antagonists, particularly their lack of need for monitoring; as a result their use is increasing. Nonetheless, the NOACs face two major challenges: the need for reliable laboratory assays to assess their anticoagulation effect, and the lack of approved antidotes to reverse their action. This article provides an overview of monitoring the anticoagulant effect of NOACs and their potential specific antidotes in development.
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Rahmat et al. (2015) studied this question.
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