Key result
Dabigatran increases INR, aPTT, and TT, with commercial TT assays being highly sensitive and exceeding test limits at 100 ng/mL in 9 of 10 reporting sites.
Why the study?
How does dabigatran affect routine coagulation screening tests (INR, aPTT, TT, and fibrinogen) in pooled normal plasma?
Population
Pooled normal plasma
Design
Preclinical, blinded
Authors
Loading...
TT over-sensitivity at low concentrations cautions against routine monitoring use; leaves open need for validated clinical assays.
How does dabigatran affect routine coagulation screening tests (INR, aPTT, TT, and fibrinogen) in pooled normal plasma?
Routine coagulation assays like INR and aPTT are unreliable for quantifying dabigatran levels due to marginal linear increases, whereas TT is highly sensitive even at low concentrations.
Dager et al. (2012) studied this question. Dabigatran was evaluated on Effect on routine coagulation screening tests (INR, aPTT, TT, and fibrinogen). Dabigatran increases INR, aPTT, and TT, with commercial TT assays being highly sensitive and exceeding test limits at 100 ng/mL in 9 of 10 reporting sites.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: