SBA-15 nanostructures enable tumor-selective delivery of Ph4Sn with enhanced anticancer activity in melanoma models

Sn suppressed the division rate of melanoma cells along with an activation of Bax and Bim mediated proapoptotic signaling pathway, supported by molecular docking studies, leading to caspase-dependent apoptosis. A significant reduction in tumor size in melanoma syngeneic model induced by s.c. inoculation of B16 cells in C57BL/6 mice revealed superior therapeutic performance of immobilized tetraphenyltin(IV) in comparison to the free compound with no observable systemic toxicity, in contrast to the severe side effects observed in animals treated with CP (cisplatin). Pharmacokinetic modeling further highlights the significant improvement in solubility, bioavailability, and tissue selectivity conferred by SBA-15 immobilization.