Key result
GYY4137 decreased systolic blood pressure and inhibited myocardial fibrosis in spontaneously hypertensive rats, and attenuated Ang II-induced fibroblast proliferation.
The hydrogen sulfide donor GYY4137 attenuates myocardial fibrosis and fibroblast proliferation, potentially via inhibition of the TGF-β1/Smad2 pathway and oxidative stress.
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Hypothesis-generating for H2S donors in hypertensive fibrosis; leaves open any clinical role pending human trials.
Meng et al. (2015) studied Myocardial fibrosis. GYY4137 was evaluated on Myocardial fibrosis and cardiac fibroblast proliferation. GYY4137 decreased systolic blood pressure and inhibited myocardial fibrosis in spontaneously hypertensive rats, and attenuated Ang II-induced fibroblast proliferation.
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