Key result
Low renin essential hypertension was not associated with excess 11-Deoxycorticosterone (DOC) production compared to normal subjects and normal renin hypertensives.
Why the study?
Are 11-Deoxycorticosterone (DOC) levels elevated in patients with low renin essential hypertension compared to normal subjects and normal renin hypertensives?
Observational (n=94)
Are 11-Deoxycorticosterone (DOC) levels elevated in patients with low renin essential hypertension compared to normal subjects and normal renin hypertensives?
The study demonstrates that 11-Deoxycorticosterone (DOC) is not elevated in low renin essential hypertension, challenging the hypothesis of DOC excess in this syndrome.
No DOC excess occurs in low renin hypertension; leaves open mineralocorticoid pathways and requires prospective confirmation.
11-Deoxycorticosterone (DOC) was determined by specific RIA in 27 normal subjects and in 25 normal renin and 23 low renin hypertensives. None of the patients exhibited unprovoked hypokalemia. Strict criteria were employed for renin profiling the hypertensive patients, including age matching, exclusion of diabetics, and the use of medications known to interfere with the renin response or with DOC measurements. In all 3 groups, comparable DOC levels were found in plasma and urine. In contrast, DOC was elevated in 7 of 19 patients with primary aldosteronism. These results do not support a DOC excess hypothesis for the syndrome of low renin essential hypertension.
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Tan et al. (1979) conducted an observational in Low renin essential hypertension (n=94). Low renin essential hypertension vs. Normal subjects and normal renin hypertensives was evaluated on 11-Deoxycorticosterone (DOC) levels in plasma and urine. Low renin essential hypertension was not associated with excess 11-Deoxycorticosterone (DOC) production compared to normal subjects and normal renin hypertensives.
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