Key result
Oxprenolol reduced blood pressure independently of basal plasma renin activity and decreased plasma renin activity in normal subjects and patients with essential hypertension.
Why the study?
Does oxprenolol affect blood pressure, plasma renin activity, and urinary sodium excretion in normal subjects and patients with essential or renovascular hypertension?
Does oxprenolol affect blood pressure, plasma renin activity, and urinary sodium excretion in normal subjects and patients with essential or renovascular hypertension?
Oxprenolol effectively lowers blood pressure in essential and renovascular hypertension regardless of baseline plasma renin activity, though its effect on renin itself depends on baseline levels.
May support oxprenolol use irrespective of renin status; leaves open prospective validation in hypertension subtypes.
The effects of beta-adrenergic blockade, using oxprenolol, were studied in plasma renin activity, urinary sodium excretion and blood pressure in ten normal subjects and in 120 patients with essential and renovascular hypertension. Blood pressure was reduced by oxprenolol administration. The hypotensive action of the drug was independent of either the basal plasma renin activity or of the plasma renin activity response. Oxprenolol decreased plasma renin activity in normal subjects and in patients with essential hypertension with normal or high basal plasma renin activity. Patients with low plasma renin activity may show a lack of response to the beta-blockade. In patients with renovascular disease the response of plasma renin activity to oxprenolol was not a discriminant factor between patients cured or not cured by surgery. Some renovascular patients were unresponsive to beta-blockade with oxprenolol.
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Salvetti et al. (1977) studied Essential and renovascular hypertension (n=130). Oxprenolol was evaluated on Plasma renin activity, urinary sodium excretion, and blood pressure. Oxprenolol reduced blood pressure independently of basal plasma renin activity and decreased plasma renin activity in normal subjects and patients with essential hypertension.
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