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Evaluates photodynamic effects of silicon phthalocyanine on melanotic cells, indicating dual action pathways.
The in vitro photodynamic effect of bis(tri-n-hexylsiloxy)silicon phthalocyanine has been evaluated against the melanotic M6 cell line. The results showed that at 10 -5 M dose, LD 50 is obtained for a 150 J cm -2 light dose and LD 90 for 540 J cm -2 . Electron spin resonance spectroscopy was used with spin traps to study the type I and type II photochemical pathways involved and to detect active oxygen intermediates such as singlet oxygen, oxygen superoxide and hydroxyl radical. The two mechanisms occurred simultaneously and no change was observed when the phthalocyanine was entrapped in liposomes.
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Decréau et al. (1998) studied this question.
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