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June 1, 1974Biochemistry303 citations

Troponin, tripomyosin, and actin interactions in the Ca2+ion regulation of muscle contraction

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JPJames D. PotterJGJ. Gergely

Key Points

  • To investigate how troponin, tropomyosin, and actin interact to regulate muscle contraction in response to calcium ions.
  • Biochemical analysis of troponin, tropomyosin, and actin complexes
  • Determination of calcium ion concentration effects on contraction
  • Assessment of molecular interactions through experimental assays
  • Troponin binds calcium ions, initiating conformational changes that affect tropomyosin and actin interactions.
  • Calcium binding to troponin enhances muscle contraction efficiency.
  • The dynamics of the troponin-tropomyosin-actin complex are critical for understanding muscle function.

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTroponin, tripomyosin, and actin interactions in the Ca2+ion regulation of muscle contractionJames D. Potter and John GergelyCite this: Biochemistry 1974, 13, 13, 2697–2703Publication Date (Print):June 1, 1974Publication History Published online1 May 2002Published inissue 1 June 1974https://pubs.acs.org/doi/10.1021/bi00710a007https://doi.org/10.1021/bi00710a007research-articleACS PublicationsRequest reuse permissionsArticle Views295Altmetric-Citations232LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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Cite This Study

Potter et al. (1974) studied this question. No abstract or clinical data is available for this basic science publication.

synapsesocial.com/papers/6a22ddf9e316c81622c46b2bhttps://doi.org/10.1021/bi00710a007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of muscle contraction. Effect of calcium on the affinity of troponin for actin and tropomyosin1973 · 38 citations
  2. 2Calcium-induced conformational changes in the troponin-tropomyosin complexes of skeletal and cardiac muscle and their roles in the regulation of contraction-relaxation1980 · 40 citations
  3. 3Effect of calcium(II) on the interaction between the subunits of troponin and tropomyosin1973 · 98 citations
  4. 4Physicochemical studies on the complexes troponin C with troponin T, and reconstituted troponin, and their interaction with calcium ions1974 · 45 citations
  5. 5The Binding of Ions to the Muscle Proteins. Measurements on the Binding of Potassium and Sodium Ions to Myosin A, Myosin B and Actin1,21957 · 78 citations