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June 1, 1980Accounts of Chemical Research

Calcium-induced conformational changes in the troponin-tropomyosin complexes of skeletal and cardiac muscle and their roles in the regulation of contraction-relaxation

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Authors

WMWilliam D. McCubbinUniversity of Alberta CKCyril M. KayUniversity of Alberta

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Implication

Characterizes Ca2+-driven troponin-tropomyosin shifts in cardiac muscle; leaves open translation to clinical myofilament therapies.

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Cite This Study

McCubbin et al. (1980) studied this question.

synapsesocial.com/papers/6a86cdfd5ee22a1e35cb9456 https://doi.org/10.1021/ar50150a004

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Physicochemical and biological studies on the metal-induced conformational change in troponin A. Implication of carboxyl groups in the binding of calcium ion1973 · 45 citations
2Interaction of troponin subunits. The interaction between the inhibitory and tropomyosin-binding subunits.1979 · 67 citations
3The interaction between beef cardiac troponin T and troponin I as demonstrated by ultraviolet absorption difference spectroscopy, circular dichroism, and gel filtration1979 · 23 citations
4Control of muscle contraction1969 · 795 citations
5Hydrodynamic and optical properties of troponin A. Demonstration of a conformational change upon binding calcium ion1972 · 139 citations