Key result
Computed tomography coronary angiography demonstrated a pooled sensitivity of 95.3% and a negative predictive value of 94.0% for detecting significant coronary artery disease in TAVI candidates.
Why the study?
Does computed tomography coronary angiography (CTCA) accurately detect significant coronary artery disease compared to invasive coronary angiography in TAVI candidates?
Population
1,275 TAVI candidates pooled from 7 studies
Comparison
Computed tomography coronary angiography (CTCA) vs Invasive coronary angiography
Design
Meta-analysis
Authors
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May reduce unnecessary invasive angiography by 37% in TAVI candidates; extends meta-analytic support for CTCA as a preprocedural gatekeeper.
Systematic Review (n=1,275)
Does computed tomography coronary angiography (CTCA) accurately detect significant coronary artery disease compared to invasive coronary angiography in TAVI candidates?
Effect estimate: Sensitivity 95.3% (95% CI 93.3-96.9)
CTCA provides high sensitivity and negative predictive value for excluding significant coronary artery disease in TAVI candidates, potentially reducing the need for routine invasive coronary angiography by 37%.
Boogert et al. (2018) conducted a systematic review in Severe aortic stenosis in patients referred for TAVI (n=1,275). Computed tomography coronary angiography (CTCA) vs. Invasive coronary angiography was evaluated on Diagnostic accuracy (sensitivity) of CTCA for detection of significant (>50% diameter stenosis) coronary artery disease (Sensitivity 95.3%, 95% CI 93.3-96.9). Computed tomography coronary angiography demonstrated a pooled sensitivity of 95.3% and a negative predictive value of 94.0% for detecting significant coronary artery disease in TAVI candidates.
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