Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2021Virus EvolutionOpen Access

The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus

View Full Paper
Ask AI
Bookmark
Share

Why the study?

SARS-CoV-1 and SARS-CoV-2 are not closely related phylogenetically yet both use human ACE2 for entry, an ability not universally shared across sarbecoviruses, leaving the evolutionary history of ACE2 usage unclear.

Population

Three sequences of a novel sarbecovirus from Rwanda and Uganda

Design

Phylogenetic analysis and in vitro functional studies

Authors

HWHeather WellsBioScientia (Poland)MLMichael LetkoWashington State UniversityGLGorka LassoAlbert Einstein College of Medicine

Discussion

Loading...

Member takes

Implication

Novel sarbecovirus sequences expand known diversity; leaves open ACE2 tropism evolution and zoonotic risk assessment.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Wells et al. (2021) studied this question.

synapsesocial.com/papers/6a22df21ba63ba012a207dbchttps://doi.org/10.1093/ve/veab007
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV)2017 · 1,316 citations
  2. 2Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity2004 · 416 citations
  3. 3A time-calibrated species-level phylogeny of bats (Chiroptera, Mammalia)2011 · 225 citations
  4. 4Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin2020 · 738 citations
  5. 5Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusion2020 · 70 citations