Key result
Cardiac CT angiography findings independently predicted major adverse cardiac events (HR 5.0; 95% CI 1.7-14.5) and showed incremental prognostic value over clinical predictors and stress testing.
Why the study?
Does cardiac CT angiography provide incremental prognostic value compared to exercise ECG and clinical predictors in patients with suspected coronary artery disease?
Cohort (n=471)
No
Does cardiac CT angiography provide incremental prognostic value compared to exercise ECG and clinical predictors in patients with suspected coronary artery disease?
Hazard Ratio: 5 (95% CI 1.7–14.5)
p-value: p=< .001
Cardiac CT angiography provides significant incremental prognostic value over traditional clinical predictors and exercise ECG for predicting major adverse cardiac events in patients with suspected CAD.
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May enhance risk stratification beyond exercise testing in suspected CAD; hypothesis-generating pending randomized trials.
Dedic et al. (2011) conducted a cohort in Suspected coronary artery disease (n=471). Cardiac computed tomographic (CT) angiography vs. Exercise electrocardiography (ECG) was evaluated on Major adverse cardiac event (MACE), defined as cardiac death, nonfatal myocardial infarction, or unstable angina requiring hospitalization and revascularization beyond 6 months (HR 5.0, 95% CI 1.7-14.5, p=< .001). Cardiac CT angiography findings independently predicted major adverse cardiac events (HR 5.0; 95% CI 1.7-14.5) and showed incremental prognostic value over clinical predictors and stress testing.
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