Key result
Atherosclerotic rabbit coronary arteries exhibited a 55% to 59% increase in maximum contraction to serotonin compared to controls, likely mediated by upregulated 5-HT1B receptors.
Atherosclerosis upregulates 5-HT1B receptors in rabbit coronary arteries, leading to enhanced serotonin-induced contraction and calcium mobilization.
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Hypothesis-generating for 5-HT1B-mediated coronary hyperreactivity in atherosclerosis; leaves open human translation and therapeutic relevance.
Ishida et al. (2001) studied Atherosclerosis. Serotonin and 5-HT1-receptor agonists vs. Control rabbit coronary arteries was evaluated on Contractile responses to serotonergic agents. Atherosclerotic rabbit coronary arteries exhibited a 55% to 59% increase in maximum contraction to serotonin compared to controls, likely mediated by upregulated 5-HT1B receptors.
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