What is the clinical evidence from this study?

Study design: Case Report. Population: Variant angina pectoris (n=4). Intervention: Exercise. Primary outcome: Coronary arterial spasm documented with arteriography.

What question did this study set out to answer?

To investigate the role of coronary arterial spasm in exercise-induced ST-segment elevation in variant angina patients.

May 1, 1979CirculationOpen Access

Coronary arterial spasm as a cause of exercise-induced ST-segment elevation in patients with variant angina.

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Key result

Exercise triggered coronary arterial spasm, inducing anginal pain and ST-segment elevation in 4 patients with variant angina.

Why the study?

Does exercise trigger coronary arterial spasm in patients with variant angina?

Population

n=4 patients with variant angina pectoris exhibiting reproducible exercise-induced chest pain and ST-segment…

Design

Case_series

Authors

GSGiorgina SpecchiaAzienda Universitaria Ospedaliera Consorziale - Policlinico Bari SSStefano De ServiInterventional Cardiology CFColomba FalconeUniversity of Pavia

Discussion

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Implication

May warrant caution during exercise testing in variant angina; hypothesis-generating case observations needing prospective confirmation.

Key Points

To investigate the role of coronary arterial spasm in exercise-induced ST-segment elevation in variant angina patients.
Examined four patients with variant angina pectoris during exercise testing.
Documented coronary arterial spasm with arteriography during ST-segment elevation in three patients.
Administered ergonovine maleate to one patient to provoke and document spasm.
All four patients exhibited reproducible exercise-induced chest pain.
Three patients experienced ST-segment elevation during exercise and arteriography confirmed spasm.
One patient demonstrated ST-segment elevation after ergonovine maleate administration.

Study Design

Type

Case Report (n=4)

Structured PICO

Does exercise trigger coronary arterial spasm in patients with variant angina?

Population

4 patients with variant angina pectoris who exhibited reproducible exercise-induced chest pain and ST-segment elevation.

Exposure

Exercise testing with arteriography (and intravenous ergonovine maleate in one patient)

Outcome

Documentation of coronary arterial spasmsurrogate

Exercise can trigger coronary arterial spasm in patients with variant angina, leading to anginal pain and ST-segment elevation.

Cite This Study

Specchia et al. (1979) conducted a case report in Variant angina pectoris (n=4). Exercise was evaluated on Coronary arterial spasm documented with arteriography. Exercise triggered coronary arterial spasm, inducing anginal pain and ST-segment elevation in 4 patients with variant angina.

synapsesocial.com/papers/6a22e266bcd0cacd21f2e320 https://doi.org/10.1161/01.cir.59.5.948

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Coronary arterial spasm as a cause of exercise-induced ST-segment elevation in patients with variant angina.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Coronary arterial spasm as a cause of exercise-induced ST-segment elevation in patients with variant angina.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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