Quantitative analysis of COOH-terminated alkanethiol SAMs on gold nanoparticle surfaces

Surface-functionalization of a self-assembled monolayer (SAM) can be achieved by introducing functional molecules at the terminal. To immobilize biomolecules on a gold substrate, COOH-terminated alkanethiol SAMs are preferably employed. Thiol molecules adsorption on gold surface was performed using thioglycolic acid (TGA, HS-CH2-COOH) monomers and a self-assembled technique.