Key result
An artificial neural network model incorporating 14 risk factors predicted cardiovascular autonomic dysfunction in a general Chinese population with a mean area under the receiver-operating curve of 0.762.
Why the study?
Does an artificial neural network model accurately predict cardiovascular autonomic dysfunction in the general Chinese population?
Cross-Sectional (n=2,092)
Does an artificial neural network model accurately predict cardiovascular autonomic dysfunction in the general Chinese population?
Effect estimate: AUC 0.762 (95% CI 0.732-0.793)
An artificial neural network model using 14 clinical variables demonstrated good discriminatory power (mean AUC 0.762) for predicting cardiovascular autonomic dysfunction in a general Chinese population.
Should not yet alter screening practices; leaves open prospective validation of the ANN model.
BACKGROUND: The present study aimed to develop an artificial neural network (ANN) based prediction model for cardiovascular autonomic (CA) dysfunction in the general population. METHODS: We analyzed a previous dataset based on a population sample consisted of 2,092 individuals aged 30-80 years. The prediction models were derived from an exploratory set using ANN analysis. Performances of these prediction models were evaluated in the validation set. RESULTS: Univariate analysis indicated that 14 risk factors showed statistically significant association with CA dysfunction (P < 0.05). The mean area under the receiver-operating curve was 0.762 (95% CI 0.732-0.793) for prediction model developed using ANN analysis. The mean sensitivity, specificity, positive and negative predictive values were similar in the prediction models was 0.751, 0.665, 0.330 and 0.924, respectively. All HL statistics were less than 15.0. CONCLUSION: ANN is an effective tool for developing prediction models with high value for predicting CA dysfunction among the general population.
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Liu et al. (2013) conducted a cross-sectional in Cardiovascular autonomic dysfunction (n=2,092). Artificial neural network (ANN) prediction model was evaluated on Mean area under the receiver-operating curve (AUC) for predicting cardiovascular autonomic dysfunction (AUC 0.762, 95% CI 0.732-0.793). An artificial neural network model incorporating 14 risk factors predicted cardiovascular autonomic dysfunction in a general Chinese population with a mean area under the receiver-operating curve of 0.762.
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